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Senior Process Development Scientist

15 May 2017

Laboratory Solutions are working with a cutting edge biotechnology company in Cambridge.

We are looking for a Senior Process Development Scientist to join our protein development team in the lab to develop and optimise protein fermentation manufacturing processes.

You will be responsible for providing efficient and effective technical leadership for both the process development and technical transfer of microbial-based fermentation projects from laboratory to plant scale. You will research and initiate new ideas.

You will be responsible for identifying and building internal tools and capability to keep the technology platform at the forefront of efficient, rational process development and scale-up and be the technical expert for the company and thus support and develop team members in this area. You will develop and optimise scale-up processes for fermentation for the production of recombinant proteins from E.coli cultures in plant-scale bioreactors.

You must be able to plan and implement feasibility studies, plan process trials, source materials and equipment, review and interpret analytical test results and data, write and implement new procedures, and liaise with R&D and manufacturing teams, within a Quality framework.

The successful candidate will have:
  • A PhD in Biochemistry, Microbiology or a related subject 
  • Strong experience in expression and optimisation of recombinant protein expression from microbial (E.coli) culture in flask and bioreactors 
  • Experience in diagnostic procedures including SDS-PAGE, off-gas analysis, glucose analysis, microbial physiology characterisation, HPLC
  • Good practical skills and a hands-on approach to implementing ideas
  • A familiarity with scale-down models and DOE is desirable
  • A familiarity with continuous centrifugation and TFF is desirable
  • Experience of the development of In-Vitro Diagnostic products, GMP and working within a quality management system is also valuable.

The successful candidate must be flexible in their approach to work and willing to work additional hours to accommodate requirements.  The enthusiasm to learn and the ability to interact and communicate effectively with colleagues at all levels within the organisation are also essential.

This role offers a scientist the chance to start working with revolutionary new technology, if interested in this permanent role then please apply today and send your cv through to matthew@lab-sol.co.uk for an initial chat!